Sulindac hepatotoxicity.
نویسندگان
چکیده
Two patients who developed painless jaundice while taking sulindac are described. Rechallenge in one case confirmed the association of hepatic damage with sulindac administration. Laboratory data and liver biopsy findings suggested a hepatitis with cholestatic features.
منابع مشابه
Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes.
Sulindac is a commonly used nonsteroidal anti-inflammatory drug. This study tested the hypothesis that sulindac-mediated drug-drug interactions and/or hepatotoxicity may be caused, in part, by inhibition of proteins responsible for the hepatic transport of drugs and/or bile acids by sulindac and/or sulindac metabolites [sulindac sulfone (S-sulfone) and sulindac sulfide (S-sulfide)]. The uptake ...
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ورودعنوان ژورنال:
- Gut
دوره 23 10 شماره
صفحات -
تاریخ انتشار 1982